WZ4003

Product Name: WZ4003
CAS No.: 1214265-58-3
Chemical Name: WZ4003
Synonyms: WZ4003;CS-1174;WZ 4003;WZ4003;N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]propanamide;N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]propanamide;N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide;Propanamide, N-[3-[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-
CBNumber: CB92707353
Molecular Formula: C25H29ClN6O3
Formula Weight: 496.99
MOL File: 1214265-58-3.mol

More

Less

WZ4003 Property

Density: 1.303±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: insoluble in H2O; ≥2.68 mg/mL in EtOH with gentle warming and ultrasonic; ≥7.85 mg/mL in DMSO with gentle warming
form: powder
pka: 14.27±0.70(Predicted)
color: white to beige

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1445
Product name: WZ4003
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $89.6
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1445
Product name: WZ4003
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $451
Updated: 2023/06/20

Cayman Chemical

Product number: 19177
Product name: WZ4003
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19177
Product name: WZ4003
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 19177
Product name: WZ4003
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

More

Less

WZ4003 Chemical Properties,Usage,Production

Uses

WZ4003 is a highly specific protein kinase inhibitor of NUAK kinases.

Biological Activity

wz4003 is a potent and selective inhibitor of nuak1 and nuak2 with ic50 values of 20 and 100 nm, respectively [1].nuak family snf1-like kinase-1 (nuak1) and the related nuak2 belong to the amp-activated protein kinase (ampk) family and are activated by liver kinase b1 (lkb1) tumour suppressor protein kinase [1].wz4003 is a potent and selective nuak1/2 inhibitor. in hek-293 cells, wz4003 inhibited the phosphorylation of myosin phosphate-targeting subunit 1 (mypt1), which was phosphorylated by nuak1 at ser445. in hek-293 cells overexpressing inhibitor-resistant nuak1[a195t], wz4003 didn’t inhibit the phosphorylation of mypt1 at ser445. in mouse embryonic fibroblasts (mefs), wz4003 significantly inhibited migration in a wound-healing assay and inhibited mefs proliferation. in a cell invasion assay, wz4003 inhibited the invasive potential of u2os cells [1]. in u2os cells, wz4003 (10 μm) inhibited phosphorylation of mypt1 and reduced the cells in s-phase by 50%. also, wz4003 prevented cells from entering into mitosis [2].

Biochem/physiol Actions

WZ4003 helps to repress the migration of cells. It also prevents cell proliferation.

storage

Store at -20°C

References

[1]. banerjee s, buhrlage sj, huang ht, et al. characterization of wz4003 and hth-01-015 as selective inhibitors of the lkb1-tumour-suppressor-activated nuak kinases. biochem j, 2014, 457(1): 215-225.
[2]. banerjee s, zagórska a, deak m, et al. interplay between polo kinase, lkb1-activated nuak1 kinase, pp1βmypt1 phosphatase complex and the scfβtrcp e3 ubiquitin ligase. biochem j, 2014, 461(2): 233-245.

WZ4003 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

WZ4003 Suppliers

China 79 India 2 The Netherlands 1 United Kingdom 2 United States 14 Global 98

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

More

Less

View Lastest Price from WZ4003 manufacturers

Career Henan Chemical Co

Product: WZ4003 1214265-58-3
Price: US $0.10/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 1g,10g,1kg
Release date: 2020-01-10

1214265-58-3, WZ4003Related Search:

WZB117 WZ3146 N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine WZ4002 WZ4141R WZ4141 MK-1775 Selumetinib BML-275 Panobinostat Ibrutinib AZD-9291

Propanamide, N-[3-[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-

WZ4003

N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]propanamide

WZ 4003;WZ4003

CS-1174

N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide

N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]propanamide

1214265-58-3

C25H29ClN6O3

Inhibitors